Hi,
To activate the Notepad replacement you find the setting on the Preferences\General tab.
Unfortunately, neither of the possibilities work for me as you can see in the attached images. They do nothing. The cleanup removes this registry setting no matter what I do.
In Wise \Settings\Exclusion panel, I added the keyword "textpad", followed by a space and then pasted "HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\Image File Execution Options\Notepad.exe\". But, I have my doubts if this is correct. Please examine the attached screenshot.
Currently, I manually deselect this each time I run the registry cleaner, since I realized that disabling the key is a very dangerous thing to do.