Report Unsafe to be removed in Wise Registry Cleaner Posted March 16 On 1/25/2022 at 12:11 PM, wisecleaner_admin said: Hello, "Unsafe" means that Wise Registry Cleaner does not know if it is safe to delete these items, and requires further judgment by the user. If you don't know them either, it is recommended to keep them. r make sure the backup function is enabled, then clean them. Wise Registry Cleaner will backup these registry entries before cleaning. If you have trouble after cleaning, please restore these registry entries from the Restore center. Thank you. Now I understand more.